Dr Fraser J Pirie

Dr Fraser J Pirie


Dr Fraser Pirie


 +27 (0)31 260 4285




Medical School / Inkosi Albert Luthuli Central Hospital

Research Interests

Diabetes & Endocrinology



List of Publications


Omar MAK, Motala AA, Seedat MA & Pirie FJ.

The significance of a positive family history in South African Indians with non-insulin-dependent diabetes (NIDDM).

Diabetes Research and Clinical Practice 1996; Suppl 34:S13 – S16.

Motala AA, Juta S, Pirie FJ, Omar MAK, Ojwang P. The role of glutamate decarboxylase (GAD) antibodies in South African Black and Indian subjects.

S Afr Med J 1999; 89: 461.

PJ Ojwang, RJ Pegoraro, PA Lanning, L Rom, A Motala, FJ Pirie, MAK Omar.

Point mutation (C 446 S) in the thyroid hormone receptor b gene in a black South African kindred with thyroid hormone resistance syndrome.

S Afr Med J 1999; 89: 1205-1210.

FJ Pirie, DF York, AA Motala, MAK Omar.

Fluorescent automated single-stranded conformation (F-SSCP) analysis is able to detect a point mutation at the extreme 5’ end of a PCR product.

Clinical Biochemistry 1999; 32: 481-484.

FJ Pirie, MG Hammond, AA Motala, MAK Omar

HLA class II antigens in South African Blacks with type 1 diabetes

Tissue Antigens 2001; 57: 348 – 352.

Madiba TE, Ramdial PK, Pirie F

Solid and cystic papillary epithelial neoplasm of the pancreas

S Afr J Surg 2000; 38: 58 – 60

FJ Pirie, AA Motala, A Amod, R Chetty, SR Thomson, S Lalloo, MAK Omar

Cushing’s syndrome caused by ectopic ACTH secretion from pulmonary tumourlets

S Afr Med J 2001; 91: 952 – 954

AA Motala, FJ Pirie, E Gouws, A Amod, MAK Omar

Microvascular complications in South African patients with long duration diabetes mellitus

S Afr Med J 2001; 91: 987 – 992

SMS Mitchell, M Vaxillaire, H Thomas, M Parrizas, Y Benmezroua, A Costa, T Hansen, KR Owen, T Tuomi, F Pirie, GU Ryffel, J Ferrer, P Froguel, AT Hattersley, TM Frayling

Rare variants identified in the HNF-4a b-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset type 2 diabetes

Diabetologia 2002; 45: 1344-1348

AA Motala, FJ Pirie, E Gouws, A Amod and MAK Omar

High incidence of Type 2 diabetes mellitus in South African Indians: a 10-year follow-up study.

Diabet Med 2003; 20: 23-30.

AA Motala, MAK Omar and FJ Pirie

Epidemiology of type 1 and type 2 diabetes in Africa

J Cardiovasc Risk 2003; 10: 77-83.

Pirie FJ. Protocols for debate: Should dexamethasone suppression tests still form part of the diagnostic evaluation of Cushing’s syndrome?

JEMDSA 2003; 8: 88-92

Hung CC, Pirie F, Luan J, Lank E, Motala A, Yeo GSH, Keogh JM, Wareham NJ, O’Rahilly S, and Farooqi IS

Studies of the Peptide YY and Neuropeptide Y2 Receptor Genes in Relation to Human Obesity and Obesity-Related Traits

Diabetes 2004; 53: 2461-2466

Pirie FJ, Pegoraro R, Motala AA, Rauff S, Rom L, Govender T and Esterhuizen T

Toll-like receptor 3 gene polymorphisms in South African Blacks with type 1 diabetes

Tissue Antigens 2005; 66: 125-131

Motala AA, Pirie F.J, Rauff S, Bacus HB

Cost-effective management of diabetes mellitus. Eth Dis. 2006 Spring; 16 (2 Suppl 2): 52-79-84

Motala AA, EsterhuizenT, Gouws E, Pirie FJ, Omar MAK.

Diabetes mellitus and other disorders of glycaemia in a rural South African community: prevalence and associated risk factors

Diabetes Care 2008; 31: 1783 – 1788

Ross I, Boulle A, Soule S, Levitt N, Pirie F, Karlsson A, Mienie J, Yang P, Wang H, She JX, Winter W, Schatz D.

Autoimmunity predominates in a large South African cohort with Addison’s disease of mainly European descent despite long-standing disease and is associated with HLA DQB*0201.

Clin Endocrinol (Oxf). 2010 Sep;73(3): 291-8

Pirie FJ, Motala AA, Pegoraro RJ, Paruk IM, Govender T and Rom L.

Variants in PPARG, KCNJ11, TCF7L2, FTO and HHEX genes in South African subjects of Zulu descent with type 2 diabetes

African Journal of Diabetes Mellitus 2010; 18 (1): 12-16.

Motala AA, Esterhuizen T, Pirie FJ, Omar MAK.

The prevalence of metabolic syndrome and determination of the optimal waist circumference cutoff points in a rural South African community.

Diabetes Care 2011; 34: 1032-1037

Gill JM, Ross A, Pirie F, Esterhuizen T.

The effect of the introduction of a standard monitoring protocol on the investigations performed on the metabolic control of type 2 diabetes at Addington Hospital Medical Outpatients Department, Durban, South Africa

S Afr Fam Pract 2012; 54(2): 151-155.

Paruk IM, Esterhuizen TM, Maharaj S, Pirie FJ, Motala AA.

Characteristics, management and outcome of primary hyperparathyroidism in South Africa: a single-centre experience

Postgrad Med J 2013; 89 (1057): 626-631. doi:10.1136/postgradmedj-2012-131707

Pirie FJ, Maharaj S, Esterhuizen TM, Paruk IM, Motala AA.

Retinopathy in subjects with type 2 diabetes at a tertiary diabetes clinic in Durban, South Africa: Clinical, biochemical and genetic factors.

Journal of Clinical and Translational Endocrinology 2014; 1: e9-e12.